NEUROPROTECTIVE ACTIVITY OF CERTAIN DERIVATIVES OF 3-HYDROXYPYRIDINE AND PYRIMIDINE WITH GLOBAL CEREBRAL ISCHEMIA IN THE EXPERIMENT

Korshunova Anna Borisovna, Postgraduate student, Mordovia State University named after N.P.Ogaryov (Saransk) , akorshunova@nm.ru
Inchina Vera Ivanovna, Doctor of medical sciences, professor, head of sub-department of clinical pharmacology, Mordovia State University named after N. P. Ogaryov (Saransk) , vinchina@mail.ru
Kostychev Nikolay Alexandrovich, Assistant, sub-department of normal physiology, Mordovia State University named after N. P. Ogaryov (Saransk), kostnikal@yandex.ru
Prosvirkina Irina Alexandrovna, Postgraduatestudent, Mordovia State University named after N.P.Ogaryov (Saransk), irishechka_82@mail.ru
Chairkin Ivan Nikolaevich, Doctor of medical sciences, professor, head of sub-department of normal anatomy, Mordovia State University named after N. P. Ogaryov (Saransk), chairkin@rambler.ru

615.21:616.831-005.4

By means of functional and histological research methods the authors have ascertained the influence of pyracetam, mexidol, xymedon, fumarate 3-hydroxipyridin on structurally functional changes of a hippocampus of the left hemi-sphere of white rats’ brain under conditions of global ischemia. On the basis of the experimental data received the authors conclude that xymedon in comparison with other drugs is the most admissible to homeostasis alignment of experimental animals.

cerebral ischemia, neuroprotection, a hippocampus, rats.